Phosphorus oxychloride → HCID 178490023, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Phosphorus oxychloride	HCID 24813	—
반응물	3-(3,4-Dimethoxyphenyl)propionyl chloride	HCID 15620702	—
반응물	1H-benzimidazole-5-carbohydrazide	HCID 16637119	—
생성물	HCID 178490023	HCID 178490023	—

반응 단계

The compound was synthesized starting from benzimidazol-5-carbohydrazide (176 mg, 1 mmol), TEA (0.153 ml; 1.1 mmol), 3,4-dimethoxyphenylpropionylchloride (228 mg, 1.1 mmol) and POCl3 (0.5 ml; 5.5 mmol) as described in method 1; yield: 0.019 mg (5.4%); MS m/z: 351.3 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.04 (t, 2H, 3J=7.5 Hz); 3.23 (t, 2H, 3J=7.5 Hz); 3.69 (s, 6H); 6.78 (dd, 1H, 4J=1.7 Hz, 3J=8.3 Hz); 6.84 (d, 1H, 3J=8.3 Hz); 6.90 (d, 1H, 4J=1.7 Hz); 7.76 (d, 1H, 3J=8.3 Hz); 7.83 (dd, 1H, 4J=1.7 Hz, 3J=8.3 Hz); 8.17 (br s, 1H), 8.40 (s, 1H); HPLC (METHOD [A]): rt 10.29 min (94.2%)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09181233B2
출처 데이터셋	uspto-grants-2015_11
ORD ID	ord-701367b8aa064b6cacf68600e54b6556
출처 메모	uspto-grants-2015_11