Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formamide → 5-tert-butyl-1H-imidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | Bromopinacolone | HCID 21642 | — |
| 반응물 | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| 생성물 | 5-tert-butyl-1H-imidazole | HCID 498436 | 21% |
반응 단계
Reaction of 1-bromo-3,3-dimethyl-butan-2-one (3.0 g, 16.80 mmol), and formamide (4.7 mL, 117.20 mmol), followed by chromatography (CH2Cl2/MeOH/NH4OH 94:3:3) gave the title compound (450 mg, 21%) as a yellow foam. 1H NMR (300 MHz, CDCl3) δ 1.29 (s, 9H), 6.77 (s, 1H), 7.57, (s, 1H). ES-MS m/z 125 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084155B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-387a8ed2067c4b49ae065cb773dcae43 |
| 출처 메모 | uspto-grants-2006_08 |