Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → 3-(3-Nitrophenylthio)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 3-Bromopyridine | HCID 12286 | — |
| 반응물 | Ethyl 2-oxocyclohexanecarboxylate | HCID 95543 | — |
| 반응물 | 3-Nitrobenzene-1-thiol | HCID 243576 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 3-(3-Nitrophenylthio)pyridine | HCID 118492332 | 43.1% |
반응 단계
3-nitrophenylmercaptan (5 g, 32 mmol), 3-bromopyridine (6.1 g, 38.6 mmol), ethyl 2-oxocyclohexylformate (1.1 g, 6.5 mmol), copper iodide (608 mg, 4.2 mmol), cesium carbonate (2.3 g, 70.6 mmol) were dissolved in 500 ml of DMSO, reacted under microwaves at 100° C. for 8 h. After being extracted with water and DCM, the organic phase was dried and separated with column chromatography to obtain an object product 3.2 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181244B1 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-a0d13f15a77e4ef9bae4bf6373c2ca64 |
| 출처 메모 | uspto-grants-2015_11 |