(+-)-3,4-Dihydroxymandelic acid → Dopac

HRID 71066

반응식

HRID 71066 반응식
C1C(CCCO)=CC(O)=C(O)C=1.[OH:13][C:14]1[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=1[OH:25])[CH:17](O)[C:18]([OH:20])=[O:19]>[Pd]>[OH:13][C:14]1[CH:15]=[C:16]([CH2:17][C:18]([OH:20])=[O:19])[CH:22]=[CH:23][C:24]=1[OH:25]

참가 물질

4

반응물 2

HCID 85782(+-)-3,4-Dihydroxymandelic acidHCID 112174641,2-Benzenediol, 4-(3-hydroxypropyl)-

생성물 1

HCID 547Dopac

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

WO 2007/009590 A1 describes a process for the preparation of hydroxytyrosol via 3,4-dihydroxymandelic acid, which is hydrogenated by metal catalysts such as palladium/carbon to give 3,4-dihydroxyphenylacetic acid. Subsequently, the reduction to hydroxytyrosol takes place. According to the examples, the hydroxytyrosol obtained has purities between 67.9% and 93.8%. Apart from one example, which describes a product with a purity of 98% without stating the pure yield by recrystallization, the precursor obtained from 3,4-dihydroxymandelic acid ester, methyl 3,4-dihydroxyphenyl acetate, is described as product with purities between 51.2% and 83.5%.

출처 및 근거

ORD 기록
ord-d4bf4cb0db6346fb92bb00b555b66035
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822738B1

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