Diethyl (2-cyanoethyl)(3,4-difluorophenyl)propanedioate → Ethyl 3-(3,4-difluorophenyl)-2-oxopiperidine-3-carboxylate

참여 물질

반응 단계

A mixture of diethyl (2-cyanoethyl)(3,4-difluorophenyl)propanedioate (15.2 g), Raney cobalt (75 g) and ammonia (2M ethanol solution, 150 mL) was stirred at room temperature for 3 days under a hydrogen atmosphere. The insoluble material was filtered off through celite, and the filtrate was concentrated under reduced pressure. The residue was washed with diisopropylether to give the title compound (10.5 g).

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