Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ferulic Acid → Sitagliptin Ferulate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ferulic Acid | HCID 445858 | — |
| 반응물 | Sitagliptin | HCID 4369359 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Sitagliptin Ferulate | HCID 178490572 | — |
반응 단계
Sitagliptin free base (4.0 gms) and ferulic acid (1.90 gms) were dissolved in ethyl acetate (32 ml) at 60° C. to 65° C. and the resultant clear solution left for slow solvent evaporation at room temperature for 48 hours. Precipitated solids were filtered off and dried at 50° C. to 55° C. for 6 hours to obtain the title compound. Yield: 3.48 gms.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181256B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-fad660d56b354869b5381b610495df64 |
| 출처 메모 | uspto-grants-2015_11 |