3-Amino-3-methylbutan-1-ol → 1-(4-Hydroxy-2-methylbutan-2-yl)-3-{4-[(trifluoromethyl)sulfanyl]phenyl}urea

HRID 711299노트

반응식

HRID 711299 반응식
[NH2:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH2:4][OH:5].[F:8][C:9]([F:21])([F:20])[S:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[C:18]=[O:19])=[CH:13][CH:12]=1>C1COCC1>[OH:5][CH2:4][CH2:3][C:2]([NH:1][C:18]([NH:17][C:14]1[CH:15]=[CH:16][C:11]([S:10][C:9]([F:20])([F:8])[F:21])=[CH:12][CH:13]=1)=[O:19])([CH3:7])[CH3:6]

참가 물질

4

반응물 2

HCID 6410003-Amino-3-methylbutan-1-olHCID 27333921-Isocyanato-4-[(trifluoromethyl)sulfanyl]benzene

생성물 1

HCID 900143591-(4-Hydroxy-2-methylbutan-2-yl)-3-{4-[(trifluoromethyl)sulfanyl]phenyl}urea수율 95%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-amino-3-methyl-butan-1-ol (941 mg, 9.12 mmol) in 10 mL THF was added 4-(trifluoromethylthio)phenylisocyanate (2.0 g, 9.12 mmol). The reaction was stirred at ambient temperature for 16 h. The solution was concentrated and subjected to a hot filtration with CH2Cl2 to give solid 1-(4-hydroxy-2-methylbutan-2-yl)-3-{4-[(trifluoromethyl)sulfanyl]phenyl}urea (95%). LCMS [M+H]+=323.1.

후처리

  1. concentrationThe solution was concentrated
  2. filtrationsubjected to a hot filtration with CH2Cl2

출처 및 근거

ORD 기록
ord-5264696445744027940e6eec42e12c59
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181261B2

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