N-(2-Acetylphenyl)acetamide → N-(2-acetyl-4-bromophenyl)acetamide
반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:13])[CH3:12])(=[O:3])[CH3:2].[Br:14]Br>CC(O)=O>[C:1]([C:4]1[CH:9]=[C:8]([Br:14])[CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:13])[CH3:12])(=[O:3])[CH3:2]참가 물질
4
실험 절차
Under N2, a pale yellow suspension of crude N-(2-acetylphenyl)acetamide (28 g, 158 mmol) in AcOH (300 mL) was stirred for about 5 min, and Br2 (12.95 mL, 253 mmol) was added within 1 h at room temperature. The resulting mixture was then stirred at room temperature for 75 min. After the reaction went to completion as monitored by LC-MS, the reaction mixture was quenched with H2O (200 mL). The mixture was filtered through Buchner funnel, and the solid was collected as N-(2-acetyl-4-bromophenyl)acetamide (35 g, yield 86%). MS (m/z): 216 (M+H)+.
후처리
- stirringThe resulting mixture was then stirred at room temperature for 75 min
- customthe reaction mixture was quenched with H2O (200 mL)
- filtrationThe mixture was filtered through Buchner funnel
출처 및 근거
- ORD 기록
- ord-9b630fec78ce435691e5aa86e1ea7c20
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09181264B2
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