N-(2-Acetylphenyl)acetamide → N-(2-acetyl-4-bromophenyl)acetamide

HRID 711387

반응식

HRID 711387 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:13])[CH3:12])(=[O:3])[CH3:2].[Br:14]Br>CC(O)=O>[C:1]([C:4]1[CH:9]=[C:8]([Br:14])[CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:13])[CH3:12])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 21306N-(2-Acetylphenyl)acetamideHCID 24408Bromine

생성물 1

HCID 459291N-(2-acetyl-4-bromophenyl)acetamide수율 86.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Under N2, a pale yellow suspension of crude N-(2-acetylphenyl)acetamide (28 g, 158 mmol) in AcOH (300 mL) was stirred for about 5 min, and Br2 (12.95 mL, 253 mmol) was added within 1 h at room temperature. The resulting mixture was then stirred at room temperature for 75 min. After the reaction went to completion as monitored by LC-MS, the reaction mixture was quenched with H2O (200 mL). The mixture was filtered through Buchner funnel, and the solid was collected as N-(2-acetyl-4-bromophenyl)acetamide (35 g, yield 86%). MS (m/z): 216 (M+H)+.

후처리

  1. stirringThe resulting mixture was then stirred at room temperature for 75 min
  2. customthe reaction mixture was quenched with H2O (200 mL)
  3. filtrationThe mixture was filtered through Buchner funnel

출처 및 근거

ORD 기록
ord-9b630fec78ce435691e5aa86e1ea7c20
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181264B2

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