Dinitrobenzonitrile → 2-{[2-(Benzyloxy)ethyl]amino}-6-nitrobenzonitrile

HRID 711897노트

반응식

HRID 711897 반응식
[CH2:1]([O:8][CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:12]([C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([N+]([O-])=O)[C:16]=1[C:17]#[N:18])([O-:14])=[O:13]>>[CH2:1]([O:8][CH2:9][CH2:10][NH:11][C:19]1[CH:20]=[CH:21][CH:22]=[C:15]([N+:12]([O-:14])=[O:13])[C:16]=1[C:17]#[N:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 520718DinitrobenzonitrileHCID 5338682-(Benzyloxy)ethanamine

생성물 1

HCID 574159982-{[2-(Benzyloxy)ethyl]amino}-6-nitrobenzonitrile수율 77%

실험 절차

Prepared as in Example 90c from 2-(benzyloxy)ethanamine and 2,6-dinitrobenzonitrile in 77% yield. 1H NMR (400 MHz, DMSO-d6) δ 3.49 (q, J=5.2 Hz, J=5.6 Hz, 2H), 3.59 (t, J=5.6 Hz, 2H), 4.49 (s, 2H), 6.47 (t, J=5.8 Hz, NH), 7.23-7.31 (m, 6H), 7.43 (d, J=8.0 Hz, 1H), 7.58 (t, J=8.4 Hz, 1H).

출처 및 근거

ORD 기록
ord-917ad38615d540e3bfcdd70f521d1938
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181276B2

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