Sulfuric Acid → Methyl 4-fluoro-3-methoxybenzoate

HRID 71193

반응식

HRID 71193 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12].S(=O)(=O)(O)O.[C:18](=O)([O-])O.[Na+]>CO>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:18])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 5984364-Fluoro-3-methoxybenzoic acid

생성물 1

HCID 592847Methyl 4-fluoro-3-methoxybenzoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-fluoro-3-methoxybenzoic acid (2.33 g) and sulfuric acid (0.2 mL) in methanol (20 mL) was heated under reflux for 10 hr, and allowed to cool to room temperature. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, the solvent was evaporated under reduced pressure, and water was added to the residue. The resultant precipitate was collected by filtration to give the title compound (2.31 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 10 hr
  3. customthe solvent was evaporated under reduced pressure, and water
  4. additionwas added to the residue
  5. filtrationThe resultant precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-e0698cf517924db49b93a7991e44b852
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822699B2

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