HCID 178526785, 화합물 → HCID 178508007, 화합물

HRID 711938노트

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HRID 711938 반응식
[N+:1]([C:4]1[C:5]([NH:13][C@H:14]2[CH2:19][CH2:18][C@H:17]([OH:20])[CH2:16][CH2:15]2)=[C:6]2[S:12][CH:11]=[CH:10][C:7]2=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[C:5]([NH:13][C@H:14]2[CH2:19][CH2:18][C@H:17]([OH:20])[CH2:16][CH2:15]2)=[C:6]2[S:12][CH:11]=[CH:10][C:7]2=[N:8][CH:9]=1

참가 물질

4

반응물 1

HCID 178526785HCID 178526785, 화합물

생성물 1

HCID 178508007HCID 178508007, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanol (50 mg, 0.2 mmol) and 10% palladium on carbon (7 mg) in methanol (2 mL) was hydrogenated under balloon pressure of H2 at room temperature for 2 h. The reaction mixture was filtered. The filtrate was concentrated to give the desired product, which was used directly in the next step. LCMS calculated for C13H18N3OS (M+H)+: m/z=264.1. Found: 264.1.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-8ee054e61b344986b32f435771e0793b
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181271B2

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