HCID 178511275, 화합물 → HCID 178511273, 화합물

HRID 711957노트

반응식

HRID 711957 반응식
[N+:1]([C:4]1[C:5]([NH:13][C@@H:14]2[CH2:19][CH2:18][C@H:17]([C:20]#[N:21])[CH2:16][CH2:15]2)=[C:6]2[S:12][CH:11]=[CH:10][C:7]2=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[C:5]([NH:13][C@@H:14]2[CH2:15][CH2:16][C@H:17]([C:20]#[N:21])[CH2:18][CH2:19]2)=[C:6]2[S:12][CH:11]=[CH:10][C:7]2=[N:8][CH:9]=1

참가 물질

4

반응물 1

HCID 178511275HCID 178511275, 화합물

생성물 1

HCID 178511273HCID 178511273, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile (32 mg, 0.10 mmol) and 10% palladium on carbon (4 mg) in methanol (1 mL) was hydrogenated under balloon pressure of H2 at room temperature for 4 h. The mixture was filtered and the filtrate was concentrated to give the desired product, which was used directly in the next step. LCMS calculated for C14H17N4S (M+H)+: m/z=273.1. Found: 273.1.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-423f3e562f6d424381ea3b453f83f17d
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181271B2

반응 노트

불러오는 중…