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Triethylamine → N-[(2S)-Bicyclo[2.2.1]hept-2-yl]-6-nitrothieno[3,2-b]pyridin-7-amine

HRID 712008
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HRID 712008 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]2[CH:11]=[CH:12][S:13][C:3]=12.[CH:14]12[CH2:20][CH:17]([CH2:18][CH2:19]1)[CH2:16][CH:15]2[NH2:21].C(N(CC)CC)C>C(O)(C)C>[CH:14]12[CH2:20][CH:17]([CH2:18][CH2:19]1)[CH2:16][C@@H:15]2[NH:21][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]2[CH:11]=[CH:12][S:13][C:3]=12
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참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 98480Exo-2-bornanamineHCID 142079507-Chloro-6-nitrothieno[3,2-b]pyridine

생성물 1

HCID 86717467N-[(2S)-Bicyclo[2.2.1]hept-2-yl]-6-nitrothieno[3,2-b]pyridin-7-amine

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
90 °C

실험 절차

A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.064 g, 0.30 mmol) (Example 1, Step 2), bicyclo[2.2.1]heptan-2-amine (from Aldrich, 0.050 g, 0.45 mmol) and triethylamine (0.083 mL, 0.60 mmol) in isopropyl alcohol (1.4 mL) was heated at 90° C. for 2 h. The mixture was concentrated to give the desired product, which was used in the next step without further purification. LCMS calculated for C14H16N3O2S (M+H)+: m/z=290.1. Found: 290.0.

후처리

  1. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-54ef6981dadd4cf3a965b36f16d96355
출처 데이터셋
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09181271B2

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