{(1R,3S)-3-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile → {(1R,3S)-3-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile

HRID 712083노트

반응식

HRID 712083 반응식
[N+:1]([C:4]1[C:5]([NH:13][C@H:14]2[CH2:18][CH2:17][C@@H:16]([CH2:19][C:20]#[N:21])[CH2:15]2)=[C:6]2[S:12][CH:11]=[CH:10][C:7]2=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[C:5]([NH:13][C@H:14]2[CH2:18][CH2:17][C@@H:16]([CH2:19][C:20]#[N:21])[CH2:15]2)=[C:6]2[S:12][CH:11]=[CH:10][C:7]2=[N:8][CH:9]=1

참가 물질

4

반응물 1

HCID 86717538{(1R,3S)-3-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile

생성물 1

HCID 86717539{(1R,3S)-3-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile수율 85.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of {(1R,3S)-3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile (8 mg, 0.03 mmol) and 10% palladium on carbon (4 mg) in methanol (0.3 mL) was stirred under an atmosphere of H2 (balloon) overnight. The mixture was filtered and concentrated to give 7 mg of the desired product. LCMS calculated for C14H17N4S (M+H)+: m/z=273.1. Found: 273.0.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4aac38411711465ca5c42645b6c8d079
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181271B2

반응 노트

불러오는 중…