Ethyl 2-azido-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate → Ethyl 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridine-7-carboxylate

HRID 71212노트

반응식

HRID 71212 반응식
[N:1]([CH:4]([CH2:10][CH2:11][CH2:12][C:13]#[C:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[O:25][C:24]([CH3:26])=[N:23][CH:22]=2)=[C:17]([O:27][CH3:28])[CH:16]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])=[N+:2]=[N-:3]>ClC1C=CC=CC=1>[CH3:28][O:27][C:17]1[CH:16]=[C:15]([C:14]2[N:3]=[N:2][N:1]3[CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:10][CH2:11][CH2:12][C:13]=23)[CH:20]=[CH:19][C:18]=1[C:21]1[O:25][C:24]([CH3:26])=[N:23][CH:22]=1

참가 물질

3

반응물 1

HCID 86662983Ethyl 2-azido-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate

생성물 1

HCID 66608315Ethyl 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridine-7-carboxylate수율 95.7%

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

반응 조건

온도
110 °C

실험 절차

A mixture of ethyl 2-azido-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate (1.40 g) in chlorobenzene (28 mL) was stirred at 110° C. for 4 hr. The reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.34 g).

후처리

  1. customThe reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-6fd409b2b3e749a49d159ed156934c72
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822699B2

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