1-tert-Butyl 4-ethyl 4-methylpiperidine-1,4-dicarboxylate → Ethyl 4-methylpiperidine-4-carboxylate hydrochloride
반응식
[CH3:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:20].O1CCOCC1>O1CCOCC1>[ClH:20].[CH3:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1참가 물질
4
실험 절차
To an ice-cold solution of O1-tert-butyl O4-ethyl 4-methylpiperidine-1,4-dicarboxylate (1 g, 3.68 mmol) in 1,4-dioxane (10 mL) was added HCl-1,4-dioxane (4.0 M, 15 mL) solution. The mixture was stirred at rt for 30 minutes. After completion of reaction (by TLC), solvent was evaporated to obtain brown solid material (0.90 g) that was carried forward to the next step without purification. MS: 172.16 [M+H]+.
후처리
- customAfter completion of reaction (by TLC), solvent
- customwas evaporated
출처 및 근거
- ORD 기록
- ord-299fe4dfdfa74898a0516eeaf7e186e2
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09181234B2
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