Ethylamine → (2,3,5-Tribromo-4-methoxy-phenyl)thiourea

HRID 712189노트

반응식

HRID 712189 반응식
[Br:1][C:2]1[C:7]([Br:8])=[C:6]([O:9][CH3:10])[C:5]([Br:11])=[CH:4][C:3]=1[NH:12][C:13]([NH:15]C(=O)OCC)=[S:14].C(N)C>>[Br:1][C:2]1[C:7]([Br:8])=[C:6]([O:9][CH3:10])[C:5]([Br:11])=[CH:4][C:3]=1[NH:12][C:13]([NH2:15])=[S:14]

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3

반응물 2

HCID 6341EthylamineHCID 86663965Ethyl N-[(2,3,5-tribromo-4-methoxy-phenyl)carbamothioyl]carbamate

생성물 1

HCID 86663966(2,3,5-Tribromo-4-methoxy-phenyl)thiourea

실험 절차

Ethyl N-[(2,3,5-tribromo-4-methoxy-phenyl)carbamothioyl]carbamate (500 mg, 1.02 mmol) was dissolved in ethylamine solution (5.09 mL, 10.18 mmol, 2 M in THF) and stirred at rt overnight. The mixture was concentrated to dryness under reduced pressure to give the desired compound as an off white solid. The mixture was used with no further purification in the next step. m/z: 416.83/418.84/420.83/422.83 [M+H]+.

후처리

  1. concentrationThe mixture was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-c09e4979c7b846c69b5eff87f87c6178
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181234B2

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