Methanol → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 712212노트

반응식

HRID 712212 반응식
C([N:8]1[CH2:13][CH2:12][C:11]([OH:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1.[CH3:18]O>[OH-].[Pd+2].[OH-]>[OH:17][C:11]1([C:14]([O:16][CH3:18])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

참가 물질

4

반응물 2

HCID 887MethanolHCID 203941814-Piperidinecarboxylicacid, 4-hydroxy-1-(phenylmethyl)-

생성물 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

시약·촉매·용매 1

HCID 9942167Palladium hydroxide촉매

실험 절차

To a stirred solution of 1-benzyl-4-hydroxypiperidine-4-carboxylic acid (1.2 g, 5.1 mmol) in MeOH (15 mL) was added palladium hydroxide and the resulting mixture was stirred at rt for 6 h under H2 atmosphere. After completion (by TLC), the mixture was passed through celite and the filtrate evaporated under reduced pressure. The crude (1 g) residue was carried forward to the next step without further purification. MS: 160.18 [M+H]+.

후처리

  1. customthe filtrate evaporated under reduced pressure
  2. customThe crude (1 g) residue was carried forward to the next step without further purification

출처 및 근거

ORD 기록
ord-11ecec35c18a44528df52b212433cdca
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181234B2

반응 노트

불러오는 중…