1,4-Dioxane hydrochloride → Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride

HRID 712220노트

반응식

HRID 712220 반응식
[F:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:20].O1CCOCC1>O1CCOCC1>[ClH:20].[F:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

참가 물질

4

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21306965Ethyl N-Boc-4-fluoropiperidine-4-carboxylate

생성물 1

HCID 24729616Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To an ice-cold solution of 1-tert-butyl 4-ethyl 4-fluoropiperidine-1,4-dicarboxylate (1.0 g, 3.89 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4.0 M, 15 mL) solution and the mixture stirred at rt for 30 min. After completion of reaction (By TLC), solvent was evaporated to obtain brownish solid material (0.78 g) that was carried forward to the next step without purification. MS: 176.20 [M+H]+.

후처리

  1. customAfter completion of reaction (By TLC), solvent
  2. customwas evaporated

출처 및 근거

ORD 기록
ord-66adb15eb9754d9baab078a1ad65a9f1
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181234B2

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