2-Benzyl-hexahydro-cyclopenta[c]pyrrole-3a-carboxylic acid methyl ester → Methyl octahydrocyclopenta[c]pyrrole-3a-carboxylate

HRID 712225노트

반응식

HRID 712225 반응식
C([N:8]1[CH2:12][C:11]2([C:16]([O:18][CH3:19])=[O:17])[CH2:13][CH2:14][CH2:15][CH:10]2[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[CH2:9]1[CH:10]2[CH2:15][CH2:14][CH2:13][C:11]2([C:16]([O:18][CH3:19])=[O:17])[CH2:12][NH:8]1

참가 물질

4

반응물 1

HCID 41183282-Benzyl-hexahydro-cyclopenta[c]pyrrole-3a-carboxylic acid methyl ester

생성물 1

HCID 66977181Methyl octahydrocyclopenta[c]pyrrole-3a-carboxylate

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

To a stirred solution of methyl 2-benzyloctahydrocyclopenta[c]pyrrole-3a-carboxylate (2.0 g, 7.69 mmol) in MeOH (15.0 mL) was added palladium hydroxide (0.20 g, 10% w/w) and the mixture stirred at rt for 16 h under H2 atmosphere. After completion of reaction (by TLC), the reaction mixture was passed through celite and the solvent evaporated. The crude (1.50 g) residue was carried forward for the next step without further purification. MS: 170.18 [M+H]+.

후처리

  1. customAfter completion of reaction (by TLC)
  2. customthe solvent evaporated
  3. customThe crude (1.50 g) residue was carried forward for the next step without further purification

출처 및 근거

ORD 기록
ord-09a6abba829b491280d5efffeeb37fb7
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181234B2

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