Thionyl Chloride → 4-Chloro-7-methoxyquinazolin-6-yl acetate

HRID 712375노트

반응식

HRID 712375 반응식
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][NH:9][C:8]2=O)(=[O:3])[CH3:2].S(Cl)([Cl:20])=O>CN(C=O)C>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[Cl:20])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 1356819606-Acetoxy-7-methoxy-3H-quinazolin-4-one

생성물 1

HCID 220221604-Chloro-7-methoxyquinazolin-6-yl acetate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

A suspension of 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate (2.00 g), DMF (0.20 mL) and thionyl chloride (30 mL) was stirred at 70° C. for 3 h. The mixture was concentrated in vacuo, and the residue was used for the next step without further purification.

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe residue was used for the next step without further purification

출처 및 근거

ORD 기록
ord-a0cb960bfa2a472d98274a925c68df95
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181277B2

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