Methanol → 1-Methyloctahydropyrrolo[3,4-b]pyridine
반응식
C([N:8]1[CH2:16][CH:15]2[CH:10]([N:11]([CH3:17])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)C1C=CC=CC=1.CO>[OH-].[OH-].[Pd+2].CCOC(C)=O>[CH3:17][N:11]1[CH2:12][CH2:13][CH2:14][CH:15]2[CH2:16][NH:8][CH2:9][CH:10]12참가 물질
5
실험 절차
To a solution of 6-benzyl-1-methyloctahydro-1H-pyrrolo[3,4-b]pyridine (2.00 g) in the mixture solvent of MeOH and EtOAc was added a catalytic amount of 20% Pd(OH)2/C. The reaction mixture was stirred for 2 h at room temperature under H2. The resulted mixture was filtered and the filtrate was concentrated to in vacuo to give the crude product, which was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 141.2 (M+1).
후처리
- filtrationThe resulted mixture was filtered
- concentrationthe filtrate was concentrated to in vacuo
출처 및 근거
- ORD 기록
- ord-ff4d879998284d0fac793ecf4944ea3c
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09181277B2
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