3,4-Dihydro-2H-pyrano[3,2-b]pyridine → HCID 68842904, 화합물

HRID 712477노트

반응식

HRID 712477 반응식
[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1>COCCO.[Pd]>[O:1]1[CH:10]2[CH:5]([NH:6][CH2:7][CH2:8][CH2:9]2)[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 124862493,4-Dihydro-2H-pyrano[3,2-b]pyridine

생성물 1

HCID 68842904HCID 68842904, 화합물수율 90%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 80192-Methoxyethanol용매

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온도
70 °C

실험 절차

To a solution of 3,4-dihydro-2H-pyrano[3,2-b]pyridine (0.60 g) in glycol monomethyl ether was added a catalytic amount of 10% Pd/C. The reaction mixture was stirred at 70° C. for 3 hours under H2 (2 MPa) and filtered. The filtrate was concentrated in vacuo to give the title compound as colorless oil (0.56 g, 90.00%), which was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 142.2 (M+1).

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-e0f1bc4483db4428b9c6b93ce7361e3c
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181277B2

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