Potassium Hydroxide → HCID 117667602, 화합물
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[N:10][CH:11]=1)[NH:8][CH2:7][CH2:6][CH2:5]2.ClC(Cl)(Cl)[C:14]([N:16]=C=O)=[O:15].[OH-].[K+]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[N:10][CH:11]=1)[N:8]([C:14]([NH2:16])=[O:15])[CH2:7][CH2:6][CH2:5]2참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a cooled (0° C.) solution of 6-bromo-1,2,3,4-tetrahydro-[1,8]naphthyridine (6.4 g, 30.0 mmol) in DCM (75 mL) is added a trichloroacetyl isocyanate (3.8 mL, 31.5 mmol). After stirring for 1 h at 0° C., a solution of methanolic KOH (1M, 10 mL) is added. The resulting mixture is allowed to warm and stir at room temperature for 16 h. The reaction is concentrated and purified by silica gel column (0-100% EtOAc in heptane) to afford the title compound (7.4 g).
후처리
- temperatureto warm
- stirringstir at room temperature for 16 h
- concentrationThe reaction is concentrated
- custompurified by silica gel column (0-100% EtOAc in heptane)
출처 및 근거
- ORD 기록
- ord-10fb7eb43d054d6da54d6dc2c3f65a8e
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09181272B2
반응 노트
불러오는 중…