[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]3[C:14](=[N:15][CH:16]=2)[NH:13][CH2:12][CH2:11][CH2:10]3)[CH:2]=1.N1C=CC=CC=1.[C:23](Cl)(=[O:25])[CH3:24].C([O-])(O)=O.[Na+]>C(Cl)Cl.O>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]3[C:14](=[N:15][CH:16]=2)[N:13]([C:23](=[O:25])[CH3:24])[CH2:12][CH2:11][CH2:10]3)[CH:2]=16-Pyridin-3-yl-1,2,3,4-tetrahydro-[1,8]naphthyridine (41 mg, 0.19 mmol) is dissolved in 2 mL of DCM and pyridine (0.19 mL, 2.3 mmol) is added into the solution. Then acetyl chloride (0.08 mL, 1.2 mmol) is added. The mixture is stirred for 0.5 hrs and saturated aqueous NaHCO3 (2 mL) is added along with water (3 mL). The mixture is extracted with EtOAc (3×10 mL) and the organic layers are combined and concentrated to give the crude product. Purification by flash column chromatography affords 37 mg of the titled product.
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