Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzimidazole → Ethyl-3-(benzimidazol-1-yl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzimidazole | HCID 5798 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ethyl 3-bromopropionate | HCID 68320 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ethyl-3-(benzimidazol-1-yl)propanoate | HCID 15878098 | 91% |
반응 단계
Ethyl-3-bromopropanoate (1.29 g, 7.1 mmol), benzimidazole (0.70 g, 5.9 mmol), and potassium carbonate (2.44 g, 17.7 mmol) were combined in anhydrous acetonitrile (60 mL) and heated to reflux for 3 days. Aqueous work-up gave ethyl-3-(benzimidazol-1-yl)propanoate (1.17 g, 91%). 1H NMR (CDCl3) δ 2.02 (s, 3H), 2.26 (m, 2H), 4.10 (t, 2H, J=6 Hz), 4.30 (t, 2H, J=6 Hz), 7.28 (br, 2H), 7.33 (br, 1H), 7.84 (br, 1H), 7.94 (br, 1H), 7.60 (br, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084155B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-2168bdfd01ef43e599b82ce28d951c97 |
| 출처 메모 | uspto-grants-2006_08 |