Benzoyl isocyanate → HCID 117667367, 화합물

HRID 712665노트

반응식

HRID 712665 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:16]=[C:17]3[C:22](=[N:23][CH:24]=2)[NH:21][CH2:20][CH2:19][CH2:18]3)[CH:12]=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]([N:33]=[C:34]=[O:35])(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:16]=[C:17]3[C:22](=[N:23][CH:24]=2)[N:21]([C:34]([NH:33][C:25](=[O:32])[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)=[O:35])[CH2:20][CH2:19][CH2:18]3)[CH:12]=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 78210Benzoyl isocyanateHCID 117667100HCID 117667100, 화합물

생성물 1

HCID 117667367HCID 117667367, 화합물수율 78.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 6-(5-benzyloxy-pyridin-3-yl)-1,2,3,4-tetrahydro-[1,8]naphthyridine (530 mg, 1.7 mmol) in DCM (18 mL) is added benzoyl isocyanate (368 mg, 2.5 mmol). The resultant mixture is heated at reflux for 2 h. The solvent is removed under vacuum to obtain N-[6-(5-benzyloxy-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carbonyl]-benzamide (620 mg).

후처리

  1. temperatureat reflux for 2 h
  2. customThe solvent is removed under vacuum

출처 및 근거

ORD 기록
ord-536b5b3f8fb24f209b995243a4975546
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181272B2

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