Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(4-Bromophenyl)ethylamine → (+/-)-N4-[1-(4-bromophenyl)ethyl]-2-chloro-5-fluoro-4-pyrimidineamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(4-Bromophenyl)ethylamine | HCID 91175 | — |
| 반응물 | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| 생성물 | (+/-)-N4-[1-(4-bromophenyl)ethyl]-2-chloro-5-fluoro-4-pyrimidineamine | HCID 22060428 | — |
반응 단계
In like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine was reacted with 1-(4-bromophenyl)ethylamine to provide (±)-N4-[1-(4-bromophenyl)ethyl]-2-chloro-5-fluoro-4-pyrimidineamine: 1H NMR (CDCl3): δ 7.88 (d, 1H, J=2.3 Hz), 7.49 (d, 2H, J=8.7 Hz), 7.25 (d, 2H, J=8.7 Hz), 4.45-5.26 (m, 2H), 1.59 (d, 3H, J=7.0 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822685B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-4b6dc13a0d914e01acd610563d9dd85d |
| 출처 메모 | uspto-grants-2014_09 |