tert-Butyl carbamate → HCID 71204722, 화합물

반응식

C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([NH:22][C:23]([C@H:25]3[CH2:29][C:28]([CH3:31])([CH3:30])[CH2:27][N:26]3C(OC(C)(C)C)=O)=[O:24])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1)=[O:12]>>[CH3:30][C:28]1([CH3:31])[CH2:27][NH:26][C@@H:25]([C:23]([NH:22][C:19]2([C:16]3[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=3)[CH2:21][CH2:20]2)=[O:24])[CH2:29]1

참가 물질

반응물 2

HCID 77922tert-Butyl carbamate

HCID 117966845HCID 117966845, 화합물

생성물 1

HCID 71204722HCID 71204722, 화합물수율 98%

실험 절차

The title compound (D108) (70 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from (R)-tert-butyl 2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-4,4-dimethylpyrrolidine-1-carboxylate (D75) (94 mg).

출처 및 근거

ORD 기록: ord-5fb6ca99036c472c87c7bae071f64b02
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09181279B2

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