Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Undecanoic Acid → 11-(2,4-Difluorophenyl)undecanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Undecanoic Acid | HCID 8180 | — |
| 반응물 | 2,4-Difluorobenzaldehyde | HCID 73770 | — |
| 반응물 | (9-Carboxynonyl)(triphenyl)phosphanium bromide | HCID 18795071 | — |
| 생성물 | 11-(2,4-Difluorophenyl)undecanoic acid | HCID 68089274 | — |
반응 단계
By the similar procedure of synthesis of B4, compound B2 (2.76 g, 5.38 mmol) and 2,4-difluorobenzaldehyde (588 mg, 4.14 mmole) were used as starting materials to afford compound B15 (431 mg, 1.45 mmol, 35%) as off-white solids. mp: 56° C. 1H-NMR (CDCl3, 400 MHz) δ 7.05-7.13 (m, 1H), 6.70-6.79 (m, 2H), 2.66 (t, J=7.6 Hz, 2H), 2.31 (t, J=7.4 Hz, 2H), 1.50-1.62 (m, 4H), 1.26 (m, 12H). 13C-NMR (CDCl3, 100 MHz) δ 180.00, 162.19, 159.80, 130.90, 125.31, 110.69, 103.44, 34.11, 30.15, 29.44, 29.36, 29.33, 29.19, 29.16, 29.03, 28.41, 24.69. HRMS (ESI) calculated for C17H24F2O2Na [M+Na]+: 321.1642, found: 321.1637.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181292B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-1484f2bd9a484a4190d341cb904e33da |
| 출처 메모 | uspto-grants-2015_11 |