4-Amino-3-nitrobenzimidamide hydrochloride → 3,4-Diaminobenzimidamide hydrochloride

HRID 712935노트

반응식

HRID 712935 반응식
[ClH:1].[NH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][C:4]=1[N+:12]([O-])=O>[OH-].[OH-].[Pd+2].CO>[ClH:1].[NH2:12][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:3]=1[NH2:2])[C:7]([NH2:9])=[NH:8]

참가 물질

4

반응물 1

HCID 673560924-Amino-3-nitrobenzimidamide hydrochloride

생성물 1

HCID 221255323,4-Diaminobenzimidamide hydrochloride

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매2회HCID 887Methanol용매

실험 절차

A suspension of 4-amino-3-nitrobenzamidine monohydrochloride (15 g, 69 mmol) and Pearlman's catalyst [Pd(OH)2, 1.0 g, 7.12 mmol) in methanol (200 mL) was shaken under hydrogen atmosphere 50 psi for 1.5 h. The suspension was filtered through Celite and the filtrate was added dropwise to anhydrous diethyl ether (400 mL) to precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid.

후처리

  1. filtrationThe suspension was filtered through Celite
  2. additionthe filtrate was added dropwise to anhydrous diethyl ether (400 mL)
  3. customto precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid

출처 및 근거

ORD 기록
ord-73d5d45d956043eca42dc6eb9221301a
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181280B2

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