2-Amino-6-methylpyridine → 2-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine

HRID 71303

반응식

HRID 71303 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=2)[C:5]([F:9])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 157652-Amino-6-methylpyridineHCID 2507052,4-Dichloro-5-fluoropyrimidine

생성물 1

HCID 220605432-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine

실험 절차

In like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine the reaction of 2,4-dichloro-5-fluoropyrimidine with 2-amino-6-methylpyridine gave 2-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine. 1H NMR (CDCl3): δ 8.23 (s, 1H), 8.19 (s, 1H), 8.12 (d, 1H, J=3 Hz), 7.55 (bs, 1H), 7.69 (t, 1H, J=7.4 Hz), 9.35 (d, 1H, J=7.5 Hz); 19F NMR (CDCl3): −44073; LCMS: purity: 96%; MS (m/e): 239 (M+).

후처리

  1. customIn like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine

출처 및 근거

ORD 기록
ord-727771ca0afc40df9ccae8d8b04bcb80
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822685B2

연결된 노트

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