Dibah → 2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-hydroxynaphthalen-7-yl)-4-pyrimidineamine

HRID 71318

반응식

HRID 71318 반응식
C1COC2(N)N(C(NC3C=CC4OC(CO)=CC=4C=3)=NC=C2F)O1.[Cl:25][C:26]1[N:31]=[C:30]([NH:32][C:33]2[CH:42]=[C:41]3[C:36]([CH2:37][CH2:38][CH2:39][C:40]3=[O:43])=[CH:35][CH:34]=2)[C:29]([F:44])=[CH:28][N:27]=1.CC(C[Al]CC(C)C)C>>[Cl:25][C:26]1[N:31]=[C:30]([NH:32][C:33]2[CH:42]=[C:41]3[C:36]([CH2:37][CH2:38][CH2:39][CH:40]3[OH:43])=[CH:35][CH:34]=2)[C:29]([F:44])=[CH:28][N:27]=1

참가 물질

4

반응물 3

HCID 16682954DibahHCID 220607872-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-oxonaphthalen-7-yl)-4-pyrimidineamineHCID 66759177N4-(3,4-ethylenedioxy)-5-fluoro-N2-[2-(hydroxymethyl)benzofuran-5-yl]-2,4-pyrimidinediamine

생성물 1

HCID 220608542-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-hydroxynaphthalen-7-yl)-4-pyrimidineamine

실험 절차

In a manner similar to the preparation of N4-(3,4-ethylenedioxy)-5-fluoro-N2-[2-(hydroxymethyl)benzofuran-5-yl]-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-oxonaphthalen-7-yl)-4-pyrimidineamine was reduced with Dibal-H to yield 2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-hydroxynaphthalen-7-yl)-4-pyrimidineamine.

출처 및 근거

ORD 기록
ord-23b0e3b606e74d3fa37152aacd7c171b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822685B2

연결된 노트

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