참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 2-Amino-6-(trifluoromethyl)pyridine | HCID 821024 | — |
| 반응물 | 3-Chloropyridine-2-carboxylic acid | HCID 824632 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 3-chloro-N-(6-trifluoromethylpyridin-2-yl)picolinamide | HCID 118113287 | 89.1% |
반응 단계
A mixture of 0.81 g of 2-amino-6-trifluoromethylpyridine, 0.78 g of 3-chloropicolinic acid, 1.15 g of EDCI hydrochloride, 0.06 g of HOBt and 10 mL of pyridine was stirred at 70° C. for 2 hours. A saturated aqueous sodium bicarbonate solution was poured to the cooled reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting solid was washed with hexane and dried to obtain 1.33 g of 3-chloro-N-(6-trifluoromethylpyridin-2-yl)picolinamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09185910B2 |
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| 출처 데이터셋 | uspto-grants-2015_11 |
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| ORD ID | ord-135b62c9e8eb46e3957a6bc97a77bb43 |
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| 출처 메모 | uspto-grants-2015_11 |
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