Ammonia → 5-(Pyrazin-2-yl)-3-(pyridin-3-yl)-1,2,4-oxadiazole

HRID 713765

반응식

HRID 713765 반응식
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[N:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:17](O)=O.N>>[N:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:17]1[O:1][N:2]=[C:3]([C:4]2[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=2)[N:10]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 10472-Pyrazinecarboxylic acidHCID 308113N-Hydroxynicotinimidamide

생성물 1

HCID 164184615-(Pyrazin-2-yl)-3-(pyridin-3-yl)-1,2,4-oxadiazole

실험 절차

The titled compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and pyrazine-2-carboxylic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.66 (ddd, J=8.0, 4.9, 1.0 Hz, 1H), 8.60 (dt, J=8.0, 1.9 Hz, 1H), 8.77 (dd, J=5.0, 1.8 Hz, 1H), 8.86-8.89 (m, 1H), 8.89-8.91 (m, 1H), 9.34 (dd, J=2.4, 0.8 Hz, 1H), 9.56 (d, J=1.6 Hz, 1H) ppm; MS (DCl/NH3) m/z 226 (M+H)+.

출처 및 근거

ORD 기록
ord-1c7554f30e2645b9b6af8c840cc3779b
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09186407B2

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