참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl cyanoacetate | HCID 7764 | — |
| 반응물 | 1,2-Dibromoethane | HCID 7839 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Ethyl 1-cyanocyclopropanecarboxylate | HCID 380810 | 176.3% |
반응 단계
Ethyl 2-cyanoacetate (0.85 g, 7.5 mmol, 1 equiv), 1,2-dibromoethane (1.3 mL, 15 mmol, 2 equiv) and K2CO3 (3.18 g, 22.5 mmol, 3 equiv) was dissolved in acetone (6 mL), and the mixture was stirred for 16 h at 80° C. The reaction mixture was filtered, concentrated to give the crude product as a yellow oil (1.84 g, 100%). 1H NMR (400 MHz, DMSO-d6) δ: 4.18 (t, 2H), 1.75 (t, 2H), 1.60 (m, 2H), 1.20 (t, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09186367B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_11 |
|---|
| ORD ID | ord-0ff2867da20e4f09bc6d2dc7550181bb |
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| 출처 메모 | uspto-grants-2015_11 |
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