2-Aminopentanenitrile → 3-(3,5-Difluorophenyl)propane-1,2-diamine

HRID 714283노트

반응식

NC(CCC)C#N.[NH2:8][CH:9]([CH2:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[CH:15]=1)[C:10]([NH2:12])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:20][C:18]1[CH:19]=[C:14]([CH2:13][CH:9]([NH2:8])[CH2:10][NH2:12])[CH:15]=[C:16]([F:21])[CH:17]=1

참가 물질

반응물 3

HCID 101712882-Aminopentanenitrile

HCID 21226445Aluminium lithium hydride

HCID 582479162-Amino-3-(3,5-difluorophenyl)propanamide

생성물 1

HCID 582477873-(3,5-Difluorophenyl)propane-1,2-diamine수율 75%

실험 절차

Following the procedure as described in Preparation 11, making variations as required to replace 2-aminopentanenitrile with 2-amino-3-(3,5-difluorophenyl)-propanamide to react with lithium aluminum hydride, 3-(3,5-difluorophenyl)propane-1,2-diamine was obtained as a colorless solid in 75% yield: The crude product was used for the next step.

후처리

customas described in Preparation 11

출처 및 근거

ORD 기록: ord-4609afaddb47449882cfad8094bf2ced
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09187426B2

반응 노트

불러오는 중…