Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluorobenzoyl chloride → N-benzyl-2-(3-fluorobenzamido)isonicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluorobenzoyl chloride | HCID 9808 | — |
| 반응물 | 3-Fluorobenzoyl chloride | HCID 74376 | — |
| 반응물 | 2-amino-N-benzylisonicotinamide | HCID 18752897 | — |
| 생성물 | N-benzyl-2-(3-fluorobenzamido)isonicotinamide | HCID 67153823 | 44% |
반응 단계
Following the procedure as describe in Example 6, making variations as required to replace 2-fluorobenzoyl chloride with 3-fluorobenzoyl chloride to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(3-fluorobenzamido)isonicotinamide was obtained as a colorless solid in 44% yield: mp 140-143° C. (hexanes/ethyl acetate); 1H NMR (300 MHz, CDCl3) δ 8.71 (s, 1H), 8.60 (s, 1H), 8.41-8.39 (m, 1H), 7.70-7.55 (m, 3H), 7.51-7.44 (m, 1H), 7.37-7.25 (m, 6H), 6.76-6.66 (m, 1H), 4.65 (d, J=5.8 Hz, 2H); MS (ES+) m/z 350.5 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09187426B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-6cb511cdb02740b8bbb32e23a7b86889 |
| 출처 메모 | uspto-grants-2015_11 |