(3-Methylpyridin-2-yl)methanol → 3-Methylpyridine-2-carboxaldehyde
반응식
[OH:1][CH2:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][N:4]=1>C(Cl)Cl.O=[Mn]=O>[CH3:9][C:8]1[C:3]([CH:2]=[O:1])=[N:4][CH:5]=[CH:6][CH:7]=1참가 물질
4
실험 절차
To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.
후처리
- filtrationthen filtered through celite
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-9b276c372b2c47e7b5b6464e07e242b6
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07084155B2
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