Trimethylsilyldiazomethane → Methyl 3-acetylbenzoate

HRID 714457노트

반응식

HRID 714457 반응식
[C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[CH3:13][Si](C=[N+]=[N-])(C)C>C1(C)C=CC=CC=1.CO.C(OCC)C>[C:1]([C:4]1[CH:5]=[C:6]([C:7]([O:9][CH3:13])=[O:8])[CH:10]=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

참가 물질

6

반응물 2

HCID 167693Trimethylsilyldiazomethane2회HCID 2203243-Acetylbenzoic acid

생성물 1

HCID 15094405Methyl 3-acetylbenzoate

시약·촉매·용매 3

HCID 887Methanol용매HCID 1140Toluene용매HCID 3283Diethyl Ether용매2회

실험 절차

3.95 g (24.06 mmol) of 3-acetylbenzoic acid were initially charged in 100 ml of toluene and 75 ml of methanol. After dropwise addition of 4.12 g (36.09 mmol) of trimethylsilyldiazomethane 2M in diethyl ether at RT, an instant evolution of gas in the reaction solution was observed. Another 0.27 g (2.4 mmol) of trimethylsilyldiazomethane 2M in diethyl ether was added until the reaction solution remained yellow, and the mixture was stirred at RT for 10 min. The reaction solution was evaporated.

후처리

  1. customThe reaction solution was evaporated

출처 및 근거

ORD 기록
ord-a4185f0c5e674338ac906d2a2b68008f
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187428B2

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