N-(3-formylphenyl)methanesulfonamide → [3-(Hydroxyethyl)phenyl](methylsulfonyl)amine

HRID 714466

반응식

HRID 714466 반응식
[CH:1]([C:3]1[CH:4]=[C:5]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1)=[O:2].[CH3:14][Mg]Br>O1CCCC1>[OH:2][CH:1]([C:3]1[CH:4]=[C:5]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1)[CH3:14]

참가 물질

4

반응물 2

HCID 2794787N-(3-formylphenyl)methanesulfonamideHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 43508614[3-(Hydroxyethyl)phenyl](methylsulfonyl)amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Under argon and at 0° C., 83 mg (0.417 mmol) of N-(3-formylphenyl)methanesulfonamide (Example 86A) were initially charged in 1 ml of abs. tetrahydrofuran. At 0° C., 99 mg (0.833 mmol) of methylmagnesium bromide (3 M in diethyl ether) were added dropwise (resulting in the formulation of a precipitate), and the reaction solution was stirred at this temperature for 2 h. The reaction solution was quenched with water and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered and evaporated.

후처리

  1. customresulting in the formulation of a precipitate), and the reaction solution
  2. customThe reaction solution was quenched with water
  3. extractionextracted three times with ethyl acetate
  4. dry with materialThe combined organic phases were dried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-9ebb46efaf6049d5b841395a69ffd1af
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187428B2

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