Dimethylformamide → HCID 67366408, 화합물

HRID 714505노트

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HRID 714505 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:25])[C:7]([C:16]3[CH:24]=[CH:23][C:19]([C:20]([OH:22])=O)=[CH:18][CH:17]=3)=[C:8]([C:12]([F:15])([F:14])[F:13])[O:9]2)=[CH:4][CH:3]=1.CCN=C=NCCCN(C)C.[C:37]([NH:44][NH2:45])([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38].CN(C=O)C>C(Cl)Cl.CCOC(C)=O>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:25])[C:7]([C:16]3[CH:17]=[CH:18][C:19]([C:20]([NH:45][NH:44][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])=[O:22])=[CH:23][CH:24]=3)=[C:8]([C:12]([F:13])([F:14])[F:15])[O:9]2)=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 70091tert-Butyl carbazateHCID 5426788HCID 5426788, 화합물

생성물 1

HCID 67366408HCID 67366408, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzoic acid (synthesis is described in PCT/US2010/024035) (1 equiv.), EDCI (1 equiv.), and BocNHNH2 (1 equiv.), in DCM and DMF (1:1) is stirred at 25° C. overnight, followed by an aqueous/EtOAc workup. Purification if necessary by column chromatography on silica gel to give the product.

후처리

  1. customPurification if necessary by column chromatography on silica gel
  2. customto give the product

출처 및 근거

ORD 기록
ord-d8ef5292aa9a4a1f90be203466bda25c
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187447B2

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