1,1'-Carbonyldiimidazole → HCID 53357308, 화합물

HRID 714507노트

반응식

HRID 714507 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:26])[C:7]([C:16]3[CH:25]=[CH:24][C:19]([C:20]([NH:22][NH2:23])=[O:21])=[CH:18][CH:17]=3)=[C:8]([C:12]([F:15])([F:14])[F:13])[O:9]2)=[CH:4][CH:3]=1.C1N=CN([C:32](N2C=NC=C2)=[O:33])C=1>C(Cl)Cl>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:26])[C:7]([C:16]3[CH:25]=[CH:24][C:19]([C:20]4[O:21][C:32](=[O:33])[NH:23][N:22]=4)=[CH:18][CH:17]=3)=[C:8]([C:12]([F:14])([F:15])[F:13])[O:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 67366697HCID 67366697, 화합물

생성물 1

HCID 53357308HCID 53357308, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzohydrazide (1 equiv.) and CDI (10 equiv.) in DCM is refluxed overnight. An aqueous/EtOAc workup followed by purification by prep-HPLC can give the desired product in Example 23.

후처리

  1. customAn aqueous/EtOAc workup followed by purification by prep-HPLC

출처 및 근거

ORD 기록
ord-0d92cb687d26480ba8e90299a36e2748
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187447B2

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