Trifluoroacetic acid → HCID 17925871, 화합물

HRID 714512노트

반응식

HRID 714512 반응식
C([O:5][C:6](=[O:19])[CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:17]([O:16][C:14]([CH:11]1[CH2:12][CH2:13][C:8](=[CH:7][C:6]([OH:19])=[O:5])[CH2:9][CH2:10]1)=[O:15])[CH3:18]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 18340695HCID 18340695, 화합물

생성물 1

HCID 17925871HCID 17925871, 화합물수율 134.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of ethyl 4-(2-tert-butoxy-2-oxoethylidene)cyclohexanecarboxylate (5.3 g, 21 mmol) in CH2Cl2 (30 ml) was added TFA (30 ml). The solution was stirred at room temperature overnight. The solution was concentrated in vacuo to afford 6 g of product as colorless oil, which was used directly for next step without further purification.

후처리

  1. concentrationThe solution was concentrated in vacuo

출처 및 근거

ORD 기록
ord-bea00d74b052408f9587690813472c8b
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187447B2

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