Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Methyl 2-(4-bromothiophen-2-yl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | Methyl thiophen-2-acetate | HCID 88055 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Methyl 2-(4-bromothiophen-2-yl)acetate | HCID 67367159 | 41.2% |
반응 단계
To a solution of methyl 2-(thiophen-2-yl)acetate (5 g, 32 m mol) and anhydrous AlCl3 (10.7 g, 80 mmol) in CHCl3 (50 ml) was added dropwise bromine (1.8 ml, 34 mmol) at 0˜5° C. over 30 min. When the addition was complete, the mixture was allowed to warm to room temperature overnight. Then it was poured into icy water (50 ml), extracted with EtOAc (30 ml×3). The combined organic phase was dried over Na2SO4, filtered and concentrated. Purification by column chromatography (PE/EtOAc=10/1) gave the product (3.1 g, 41%) as light yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09187447B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-c684f8a700ae4cda99395bea95117d31 |
| 출처 메모 | uspto-grants-2015_11 |