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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 71462생성일: 2026년 10월 25일

5-Aminoindole → 5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-5-yl]-2,4-pyrimidinediamine

https://huagongshe.com/reaction/71462

반응식

참여 물질

역할이름HCID투입량
반응물5-AminoindoleHCID 78867—
반응물N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-primidinediamineHCID 22060334—
반응물2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamineHCID 22060451—
생성물5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-5-yl]-2,4-pyrimidinediamineHCID 22060277—

반응 단계

In a manner similar to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine and 5-aminoindole were reacted to yield 5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-5-yl]-2,4-pyrimidinediamine. LCMS: ret. time: 17.31 min.; purity: 94%; MS (m/e): 366 (MH+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08822685B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-968da899369b47a3a4ec74c26ecac2e0
출처 메모uspto-grants-2014_09