Potassium Carbonate → 5-(4-Chlorophenyl)-4-cyclopropyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

반응식

O[CH2:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[CH3:8].[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:17]([CH:22]3[CH2:24][CH2:23]3)[C:18](=[O:21])[NH:19][N:20]=2)=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>>[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[N:17]([CH:22]3[CH2:24][CH2:23]3)[C:18](=[O:21])[N:19]([CH2:2][C:3]3[N:4]=[CH:5][NH:6][C:7]=3[CH3:8])[N:20]=2)=[CH:14][CH:15]=1

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 1224334-hydroxymethyl-5-methyl-1H-imidazole

HCID 580121993-(4-Chlorophenyl)-4-cyclopropyl-1H-1,2,4-triazol-5(4H)-one

생성물 1

HCID 699403485-(4-Chlorophenyl)-4-cyclopropyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

실험 절차

Analogously to the compound in Example 96A, 181 mg (1.62 mmol) of 4-hydroxymethyl-5-methyl-1H-imidazole, 381 mg (1.62 mmol) of 5-(4-chlorophenyl)-4-cyclopropyl-2,4-dihydro-3H-1,2,4-triazol-3-one [preparation according to WO 2007/134862 Example 36A] and 670 mg (4.85 mmol) of potassium carbonate were reacted with one another. This gave 180 mg (47% of theory) of the target compound in a purity of 76%.