Sodium Methoxide → HCID 178497762, 화합물

HRID 714681노트

반응식

HRID 714681 반응식
Br.[F:2][C:3]([F:15])([F:14])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11](=[NH:13])[NH2:12].C[O-].[Na+].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:30]([CH2:31][C:32]3[CH:33]=[C:34]([C:38]([O:40][CH3:41])=[O:39])[CH:35]=[CH:36][CH:37]=3)[C:29](=[O:42])[N:28]([CH2:43][C:44]([NH:46]N)=O)[N:27]=2)=[CH:22][CH:21]=1>CO>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:30]([CH2:31][C:32]3[CH:33]=[C:34]([C:38]([O:40][CH3:41])=[O:39])[CH:35]=[CH:36][CH:37]=3)[C:29](=[O:42])[N:28]([CH2:43][C:44]3[NH:12][C:11]([CH2:10][C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[C:3]([F:14])([F:15])[F:2])=[N:13][N:46]=3)[N:27]=2)=[CH:22][CH:21]=1

참가 물질

5

반응물 3

HCID 10942334Sodium MethoxideHCID 673965422-[2-(Trifluoromethyl)phenyl]ethaneimidamide hydrobromideHCID 69940030Methyl 3-{[3-(4-chlorophenyl)-1-(2-hydrazino-2-oxoethyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]methyl}benzenecarboxylate

생성물 1

HCID 178497762HCID 178497762, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

77 mg (0.27 mmol) of 2-[2-(trifluoromethyl)phenyl]ethaneimidamide hydrobromide were dissolved in 1 ml of dry methanol, 74 μl (0.27 mmol) of a 25% strength methanolic sodium methoxide solution were added and the mixture was stirred for 30 min 75 mg (0.18 mmol) of the compound from Example 16A were then added, and the mixture was stirred initially at RT for 16 h and then under reflux for 5 h. The mixture was then directly purified chromatographically [Method 19]. This gave 67 mg (64% of theory) of the target compound as a colorless foam.

후처리

  1. additionwere then added
  2. temperatureunder reflux for 5 h
  3. customThe mixture was then directly purified chromatographically [Method 19]

출처 및 근거

ORD 기록
ord-28b9a73569e54cbaaf95393077f47b5f
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187466B2

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