2-Chlorophenylboronic acid → HCID 69940488, 화합물

반응식

Br[C:2]1[CH:3]=[CH:4][C:5]([F:25])=[C:6]([CH:24]=1)[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH:14]2[CH2:16][CH2:15]2)[C:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[N:9]1.[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1B(O)O>>[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:2]1[CH:3]=[CH:4][C:5]([F:25])=[C:6]([CH2:7][N:8]2[C:12](=[O:13])[N:11]([CH:14]3[CH2:16][CH2:15]3)[C:10]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)=[N:9]2)[CH:24]=1

참가 물질

반응물 2

HCID 27343222-Chlorophenylboronic acid

HCID 67407291HCID 67407291, 화합물

생성물 1

HCID 69940488HCID 69940488, 화합물

실험 절차

Analogously to the preparation of Example 122, 89 mg (0.15 mmol) of the compound from Example 100A were reacted with 59 mg (0.23 mmol) of 2-chlorophenylboronic acid. This gave 51 mg (73% of theory) of the target compound.

출처 및 근거

ORD 기록: ord-f36d21cd0a9441b9826772eafa71a1ae
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09187466B2

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