2-(Trifluoromethyl)benzeneboronic acid → HCID 86690942, 화합물

반응식

Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][N:13]2[C:17](=[O:18])[N:16]([CH2:19][CH:20]([OH:25])[C:21]([F:24])([F:23])[F:22])[C:15]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)=[N:14]2)[CH:3]=1.[F:33][C:34]([F:45])([F:44])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1B(O)O>>[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([C:15]2[N:16]([CH2:19][CH:20]([OH:25])[C:21]([F:24])([F:22])[F:23])[C:17](=[O:18])[N:13]([CH2:12][C:4]3[CH:3]=[C:2]([C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=4[C:34]([F:45])([F:44])[F:33])[CH:11]=[CH:10][C:5]=3[C:6]([O:8][CH3:9])=[O:7])[N:14]=2)=[CH:27][CH:28]=1

참가 물질

반응물 2

HCID 27343872-(Trifluoromethyl)benzeneboronic acid

HCID 69939744HCID 69939744, 화합물

생성물 1

HCID 86690942HCID 86690942, 화합물

실험 절차

Analogously to the preparation of Example 122, 265 mg (0.50 mmol) of the compound from Example 104A were reacted with 149 mg (0.74 mmol) of 2-(trifluoromethyl)phenylboronic acid. This gave 113 mg (38% of theory) of the target compound of a purity of 100% and 101 mg (28% of theory) of a purity of 81%.

출처 및 근거

ORD 기록: ord-5ddec0467fab46de868f6d41cb53e148
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09187466B2

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